Endocrine Abstracts

PCOS is a complex genetic disease resulting from the interplay between susceptibility genes and environmental factors. The syndrome is characterized by hyperandrogenism, disordered gonadotropin secretion, profound insulin resistance and, frequently, obesity. It is a leading risk factor for type 2 diabetes mellitus and MBS in adolescent and young adult women. In PCOS, MBS risk increases with increasing androgen levels, independent of insulin resistance and obesity, and antagoni...

PCOS is a complex genetic disease resulting from the interplay between susceptibility genes and environmental factors. Hyperandrogenemia consistent with an alteration in ovarian and adrenal steroidogenesis is the major reproductive phenotype in families of women with PCOS, including mothers and brothers. Reproductive age sisters have two affected phenotypes: (1) hyperandrogenemia and chronic anovulation or (2) hyperandrogenemia with regular menses and apparently normal fertili...

Andrea Dunaif, Northwestern University, Feinberg School of Medicine, Chicago, United States. AbstractDr Dunaif received her MD from Columbia University College of Physicians and Surgeons, trained in New York and Boston and rose to rank of Associate Professor at the Mount Sinai School of Medicine. Since 1992 Dr Dunaif has held posts at Brigham and Women’s Hospital as Director of Women’s Health and Chief of the...

Introduction: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is diagnosed based on three criteria, including a polycystic ovarian morphology. Moreover, women with PCOS have elevated serum Anti-Müllerian Hormone (AMH) levels, a hormone known to correlate with follicle number. In addition, AMH production per follicle is suggested to be higher in PCOS. Little is known about AMH gene regulation. Hence, this study aims to inv...